Randomized controlled study for assessing effectiveness of hypercapnia on quality of emergence from general anesthesia in adults

Randomized controlled study for assessing effectiveness of hypercapnia on quality of emergence from general anesthesia in adults - hypercapnia and quality of emergence from general anesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020143

Enrollment

Registered

2015-12-10

Start date

2015-12-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult patients undergoing abdominal sugeries under general anesthesia combined with epidural anesthesia

Interventions

normocapnia: ET-CO2 30-35 mmHg is maintained until emergence from anesthesia. hypercapnia: ET-CO2 is gradually reduced from 60-65 mmHg until emergence from anesthesia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for invasive arterial blood pressure monitoring 2. Patients scheduled for general anesthesia combined with epidural anesthesia 3. Patients undergoing abdominal surgeries

Exclusion criteria

Exclusion criteria: 1. Patients with ASA (American Society of Anesthesiologists) physical status greater than 3 2. Patients with abnormal upper airway 3. Patients with asthma 4. Patients with post-head and neck surgeries 5. Patients with COPD (%FEV1.0<70%) 6. Patients with tracheostomy 7. Patients with intra-cranial pathologies 8. Patients with hypoxemia at emergence from anesthesia 9. Patients without indication for extubation in the operating room

Design outcomes

Primary

Measure	Time frame
emergence time from cessation of general anesthetics	—

Secondary

Measure	Time frame
Critical cardio-respiratory events	—

Countries

Japan

Contacts

Public ContactShiroh Isono

Graduate School of Medicine, Chiba University Department of Anesthesiology

shirohisono@yahoo.co.jp043-222-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026