Defining a novel law of glucose homeostasis under SGLT-2 inhibitor usage by mathematical model approch

Defining a novel law of glucose homeostasis under SGLT-2 inhibitor usage by mathematical model approch - Defining a novel law of glucose homeostasis under SGLT-2 inhibitor usage by mathematical model approch

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020141

Enrollment

100

Registered

2015-12-10

Start date

2016-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes

Interventions

SGLT-2 inhibitor (Dapagliflozin) 5 mg per day 5 conseqtive days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)T2DM who are naive to SGLT-2 inhibitor 2) 20-75 years old 3 having a will to attend this study

Exclusion criteria

Exclusion criteria: 1) pregnant or breast-feeding 2) insulin antibody positive (>10 arbitrary unit ) 3) having allergy of skin trouble for oral hypoglycemic agants or insulin 4) type 1 diabetes or other specific type of diabetes 5) severe liver dysfunction (transaminase twice over the normal limit) 6) severe renal dysfunction (eGFR<50) 7) severe heart failure(NYHA>2) 8) long-acting insulin, long-acting GLP-1 RA, or long-acting DPP-4 inhibitor user 9) psychologic disorder 10) recent severe hypoglycemia or hypoglycemia unawareness 11) contraindication of dapagliflozin others inappropriate for this study

Design outcomes

Primary

Measure	Time frame
To determine the parameters of the novel mathematical model for glucose homeostasis with the use of OGTT and hyperinsulinemic-euglycemic clamp data identify novel relationship of the parameter	—

Countries

Japan

Contacts

Public ContactKazuhiko Sakaguchi

Kobe University School of Medicine Division of Diabetes and Endocrinology Department of Internal Medicine

kzhkskgc@med.kobe-u.ac.jp81-78-382-5861

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026