Healthy volunteers
Conditions
Interventions
Theaflavin tablet, 8 mg/2tablets/day, 6 weeks
Placebo tablet, 0 mg/2 tablets/day, 6 weeks
Sponsors
University of Shizuoka
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects who are not appropriate to examine oral bacterial flora 2. Subjects who are not under treatment for dental caries and/or periodontal disease and have enough tooth (20 tooth<=)
Exclusion criteria
Exclusion criteria: 1. Subjects who are under treatment with mouse rinse 2. Subjects with diabetes, CKD, gastrointestinal diseases, lung diseases and/or cancer. 3. Subjects who are not appropriate to amount and pH of saliva. 4. Subjects with dental caries and/or periodontal disease 5. Subjects using removable denture 6. Antibiotics 7. drug and/or alcohol dependence 8. Pregnancy and nursing 9. Subjects who participate in other clinical trials at the time of this study entry
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Periodontopathic-bacteria after taking teaflavin tablets for 3 or 6 weeks (1.P.gingivalis 2.F.nucleatum) | — |
Secondary
| Measure | Time frame |
|---|---|
| Following indicators after taking teaflavin tablets for 3 or 6 weeks 1) Gingival index:GI 2) Plaque index: PI 3) Bleeding on Probing: BOP 4) Cariogenic bacteria | — |
Countries
Japan
Contacts
Public ContactEiji Yoshikawa
KSO Corporation Sales department
Outcome results
None listed