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Sevoflurane Dexmedetomidine or Fentanyl in neuroanesthesia for infants, a randomised control trial

Sevoflurane Dexmedetomidine or Fentanyl in neuroanesthesia for infants, a randomised control trial - analgesia and sedative effects of dexmedetomidine and fentanyl on infants scheduled for neurosurgical procedures

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000020014
Enrollment
60
Registered
2016-06-30
Start date
2015-12-30
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prospective randomized controlled trail

Interventions

1micg/kg dexmedetomedine slowly intravenously and 0.5 mg/kg atracuoruim and intubated with an endotracheal tube of suitable size Patients will receive Hartman&#39
s solution in 5% glucose solution at the ratio 3:1 as by Segar formula. Patients will be ventilated by pressure controlled mode, inspiratory pressure = 20 cmH2O, and rate will be adjusted to maintain
s solution in 5% glucose solution at the ratio 3:1 as by Segar formula. Patients will be ventilated by pressure controlled m

Sponsors

Mansoura university , Faculty of medicine, Department of anesthesia and surgical intensive care,Devision of Neuro anesthesia
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: . It will include patients 2 years old and younger of both gender; after obtaining informed signed consent from patients guardians; who will be schedule for neurosurgical procedures. patients must be older than 44 weeks post gestation

Exclusion criteria

Exclusion criteria: younger than 44 weeks post gestational, with known cardiovascular diseases, renal diseases, hepatic diseases, pulmonary diseases, systemic or local infection will be excluded from this study.

Design outcomes

Primary

MeasureTime frame
the perioperative Face, leg agitation, cry and consoability( FLACC) scores relating to pain and agitation in infants

Secondary

MeasureTime frame
Changes in hemodynamic both intra and post operatively will supplement our primary outcomes.

Countries

Africa

Contacts

Public ContactFatma MF Lahloub

Mansoura university , Faculty of medicine, Department of anesthesia and surgical intensive care Neuro anesthesia

flahloub@mans.edu.eg+201006288357

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026