None
Conditions
Interventions
Bitter components derived from hops, once a day, 4 weeks
Sponsors
HUMA R&D CORP
The University of Tokyo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects aged from 50 to 70 years old 2) Subjects who are healthy, right-handed, and have Japanese Nationalities. 3) Subjects who do not intake alcoholic beverages and foods and bevarages containning hops, or intake less than one day a week. 4) Subjects who can refrain from intake of foods and bevarages containning hops during the current study. 5) Subjects who do not satisfy key exclusion criteria.
Exclusion criteria
Exclusion criteria: 1) Subjects who have a smoking habit. 2) Subjects with serious hepatic, renal, and cardiovascular dysfunction (including anamnesis). 3) Subjects who are constantly being treated by drugs. 4) Subjects who are being treated by kinesiology, or dietary cure under control by doctors. 5) Subjects with medicine allergy, or food allergy. 6) Subjects with drug dependence, or drug abuse (including anamnesis). 7) Subjects who work at night, or work irregularly. 8) Subjects who are pregnant or lactating, or planned to become pregnant. 9) Subjects who participate in other clinical studies. 10) Subjects with artificial cardiac pacemakers. 11) Subjects with vascular clips. 12) Subjects with Electrical stimulator for nerves. 13) Subjects with embedded pumps. 14) Subjects who have piece of metals in their bodies by some reasons (including accidents or injured) 15) Subjects with tattoos 16) Subjects who have piece of metals or screws in their bodies by some treatment, such as broken bones. 17) Subjects who dye their hair by coloring containing metals. 18) Subjects with glycerin patches. 19) Subjects with artifacts in their ears. 20) Subjects with injuries by metals. 21) Subjects who have experiences of surgery. 22) Subjects with intrauterine devices. 23) Subjects with dental instruments containing metals. 24) Subjects with artificial eyes. 25) Subjects who have experiences of labyrinth disease such as Meniere's disease. 26) Subjects with artificial cardiac valves. 27) Subjects with claustrophobia or nyctophobia. 28) Subjects with dyskinesia. 29) Subjects with severe visual disorder or hearing impairments. 30) Subjects who have experiences of heart seizures. 31) Subjects who have experiences of epileptic seizures. 32) Subjects with migraines. 33) Subjects who have had bad feelings seeing sparkling lights. 34)Subjects who have occupational history of polishing metals.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| <Efficacy> Measurements of brain images using fMRI after intervention for 4 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| <Efficacy> Questionnaires. | — |
Countries
Japan
Contacts
Public ContactToshiki Kataoka
HUMA R&D CORP Business Promotion Division
Outcome results
None listed