healthy adult volunteers
Conditions
Interventions
Tonic CS is applied to the forearm by QTSD with a pain intensity of 70 on VAS (0-100) for about 6 minutes. For CPM evaluation, PPT is measured at contralateral forearm before, during, and after CS.
Sponsors
Division of Dental Anesthesiology, Department of Diagnostic and Therapeutic Sciences, School of Dentistry, Meikai University
Center for Sensory-Motor Interaction (SMI), Aalborg University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: healthy adult volunteers after informed consent is obtained
Exclusion criteria
Exclusion criteria: (1) a medical condition such as neurological, psychiatric diseases; (2) the inability to give informed consent; and (3) the current use of analgesic drugs, anti-depressants, or cough suppressants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CPM effect Evaluation of CPM effect is assessed by Quantitative Sensory Testing (QST) such as Pressure Pain threshold measured by pressure algometer or threshold measured by von Frey filament as subjective evaluation and objective evaluation by Visual Analogue Scale (VAS) etc. The CPM effect is evaluated during and after conditioning stimulation. CPM effect is defined as ratio of pain threshold of TS during CS to pain threshold before application of CS (baseline). | — |
Secondary
| Measure | Time frame |
|---|---|
| modulation of sensation by QTSD | — |
Countries
Japan
Contacts
Public ContactHikaru Kohase
Department of Diagnostic and Therapeutic Sciences, School of Dentistry, Meikai University Division of Dental Anesthesiology
Outcome results
None listed