Study on association between beta cell function and glycemic variability in the non-diabetic subjects with normal glucose tolerance and impaired glucose tolerance

Study on association between beta cell function and glycemic variability in the non-diabetic subjects with normal glucose tolerance and impaired glucose tolerance - Study on association between beta cell function and glycemic variability in the non-diabetic subjects with normal glucose tolerance and impaired glucose tolerance

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000020002

Enrollment

100

Registered

2015-12-01

Start date

2015-11-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.without diabetes mellitus 2.20 years of age or older 3.before the study, able to understand our explanation on the study and obtain the written informed consent based on their own free will

Exclusion criteria

Exclusion criteria: 1.the use of medications that affect glucose metabolism (such as corticosteroids, beta-blockers) 2.existing or possible pregnancy 3.brestfeeding 4.an investigator's declaration that the participant was otherwise inappropriate for the study

Design outcomes

Primary

Measure	Time frame
Association between the parameters of glycemic variability calculated from the continuous glucose monitoring data and the index of beta cell function calculated from the data of hyperglycemic clamp and euglycemic hyperinsulinemic clamp	—

Secondary

Measure	Time frame
1.Association between the parameters of glycemic variability calculated from the continous glucose monitoring data and the index of beta cell function calculated from the date of 75g oral glucose tolerance test (75g OGTT) 2.Association between the indices of beta cell function calculated from the data of 75g OGTT and glucose clamp 3.Association between anthropometric data, serum lipid profile, basal metabolic rate measured with indirect calorimeter and the parameters of glycemic variability or the indices of beta cell function	—

Measure

Time frame

1.Association between the parameters of glycemic variability calculated from the continous glucose monitoring data and the index of beta cell function calculated from the date of 75g oral glucose tolerance test (75g OGTT) 2.Association between the indices of beta cell function calculated from the data of 75g OGTT and glucose clamp 3.Association between anthropometric data, serum lipid profile, basal metabolic rate measured with indirect calorimeter and the parameters of glycemic variability or the indices of beta cell function

—

Countries

Japan

Contacts

Public ContactTomoaki Nakamura

Kobe University Graduate School of Medicine Division of Diabetes and Endocrinology

tomnak@med.kobe-u.ac.jp078-382-5111

Outcome results