Change of microbiota of oral cavity, stomach and intestine by administration of lansoprazole and vonoprazan

Change of microbiota of oral cavity, stomach and intestine by administration of lansoprazole and vonoprazan - Change of microbiota by lansoprazole and vonoprazan

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019998

Enrollment

Registered

2015-12-15

Start date

2015-12-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

1. Lansoprazole 30mg once daily dosing 28 days 2. Washout periods: 28 days 3. Vonoprazan 20mg once daily dosing 28 days 1. Vonoprazan 20mg once daily dosing 28 days 2. Washout periods: 28 days 3.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers at age of 20-50 years old with informed consent 2. Performance status: 0 3. H. pylori-negative 4. CYP2C19 genotype: poor metabolizer and rapid metabolizer

Exclusion criteria

Exclusion criteria: 1. With medication of anti-microbial agents within three months. 2. With medication of anti-gastric acid inhibitory drug within three months. 3. With malignant diseases and severe complications 4. With mediaction of drug in relation with CYP3A4 pathway 5. With medication of corticosteroid 6. With active peptic ulcer 7. With severe complication, such as heart failure, renal failure and respiratory failure 8. With allergy for lansoprazole or vonoprazan 9. H. pylori-positive patients 10. Pregnancy 11. No informed consent

Design outcomes

Primary

Measure	Time frame
Changes of microbiota in oral cavity, stomach and intestine between before and after administration of lansoprazole and vonoprazan	—

Secondary

Measure	Time frame
(1) Change of serum gastrin level	—

Countries

Japan

Contacts

Public ContactMitsushige Sugimoto

Shiga University of Medical Science Hospital Division of Digestive Endoscopy

sugimo@belle.shiga-med.ac.jp077-548-2618

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026