normal condition
Conditions
Interventions
administration of L-cystein releasing troches
administration of placebo troches
Sponsors
Division of Gastroenterology, Tohoku University Graduate School of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. The subjects with written informed consent 2. H. pylori-negative male subjects with 20 years or more 3. ALDH2-active or ALDH2-deficient subjects
Exclusion criteria
Exclusion criteria: 1. Current smoker 2. The subjects after resection of gastrointestinal tract or truncal vagotomy 3. The subjects with ongoing therapy for any disease 4. The subjects with taking drugs except for L-cysteine troches during this study 5. The subjects who cannot drink any alcohol 6. The subjects with past history of allergy for any drug 7. The subjects with past history of liver, kidney or heart disease 8. The subjects that this study researcher regards as inappropriate for participating in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The comparison of acetaldehyde concentration in esophageal biopsy specimen after alcohol intake between ALDH2-active and ALDH2-deficient subjects | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The comparison of acetaldehyde concentration in esophageal biopsy specimen after alcohol intake between ALDH2-active and ALDH2-deficient subjects in administrating slowly L-cysteine releasing troches 2. The comparison of acetaldehyde concentration in blood, saliva, and esophageal biopsy specimen of ALDH2-active and ALDH2-deficient subjects in each condition of administration of slowly L-cysteine releasing troches and non-administration 3. The comparison of acetaldehyde concentration in esophageal and gastric biopsy specimen in each condition of administration of slowly L-cysteine releasing troches and non-administration | — |
Countries
Japan
Contacts
Public ContactWaku Hatta
Tohoku University Graduate School of Medicine Division of Gastroenterology
Outcome results
None listed