postviral olfactory dysfunction
Conditions
Interventions
valproic acid Tab (200mg tablet), Sig: 1 tablet po BID for 24 weeks
Sponsors
Shiga university of Medical Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients are diagnosed to be a postviral olfactory dysfunction 2) Male patients of 20 or older and younger than 80 at the time of obtaining their consents, and Postmenopausal female patients younger than 65 3) Patients who understand the substances of this Trial and can consent in writing
Exclusion criteria
Exclusion criteria: Exclusion Criteria concerning Diagnosis 1)Patients taking Carbapenem,Barbituric acid,phenytoin, Carbamazepine, ethosuximide, amitriptyline, clobazam, lamotrigine, salicylic acid, Benzodiazepine, warfarin, erythromycin, cimetidine, clonazepam) 2) Patients having a history of serious drug allergies 3) Patients with severe depression, suicidal thinking or suicide attempt or past history of any of these diseases 4) Patients with liver dysfunction 5) Patients with renal dysfunction 6) Female patients having fertility 7) Patients with urea cycle abnormality 8) Patients with past history of an encephalopathy or a coma caused by unknown 9) Patients having a family member with urea cycle abnormality or who experience infant death 10) Patients with subjective olfactory loss before onset of postviral olfactory dysfunction 11) Patients who are otherwise judged unfit as a subject for this trial by a principal investigator or investigators participating in this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes of average recognition threshold scores measured by T and T olfactometer before and after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| changes of scores before and after treatment (visual analog scale and 5 grading scale of subjective symptoms, score measured by the odor stick identification test for Japanese, and average detection threshold scores measured by T and T olfactometer) | — |
Countries
Japan
Contacts
Public ContactTakao Ogawa
Shiga university of Medical Science otorhinolaryngology
Outcome results
None listed