Healthy adults
Conditions
Interventions
Apply the physical therapy and the placebo therapy for skin around eye and mouth area for 10 minutes once every 2 days for 8 weeks.
Sponsors
Kao Corporation
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: -Healthy males -Subjects who have no habit of taking coffee more than 3 cups per day
Exclusion criteria
Exclusion criteria: -Subjects with cutaneous symptoms of atopic dermatitis -Subjects with clinically-significant disorder (wound and eczema etc.) at the test site -Subjects with excess sunburn at the test site -Subjects who take daily application of medicine such as hormone preparation and cosmetics, and medicine for melanosis (chloasma, pigmented spots etc.) -Subjects who see a doctor regularly or had a routine visit to a clinic within the past 1 month for disease (gastrointestinal system, liver, kidney, heart, blood pressure, skin, and physical deconditioning). (Manual therapy, chiropractic and massage are not included) -Subjects who suffer from disease relevance to vascular function (hypertension, heart disease, diabetes mellitus, Raynaud disease, rosacea, telangiectasia) and severe feeling of cold -Subjects who had trouble in electrocardiography in the past (abnormal cardiac rhythm) -Subject who are taking OTC or prescription medicine( ex. hypnotic, anti-allergic agent, hormone preparation, cathartic, intestinal regulator, and others) -Subjects who suffer from pollinosis, rhinitis, and allergic dermatitis(atopic dermatitis) and who have clinical suspicions of these disease -Subjects known or suspected to be drug allergy -Subjects who habitually take much (over three cups per day) coffee per day -Subjects who smoke -Subjects who participated in another clinical study accompanied by topical application of formulations and tape stripping treatment to the site to be studied within the past 1month -Subjects deemed inappropriate to participate in this study by the principle investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Change of stratum corneum water content after 8 weeks of physical therapy treatment -Change of trans epidermal water loss after 8 weeks of physical therapy treatment -Change of skin color after 8 weeks of physical therapy treatment -Change of skin viscoelasticity after 8weeks of physical therapy treatment -Change of shape of skin surface after 8 weeks of physical therapy treatment -Change of blood vessel function after 8 weeks of physical therapy treatment | — |
Countries
Japan
Contacts
Public ContactJunko Kitano
Kao Corporation R&D-Core Technology-Biological Science Research
Outcome results
None listed