Prospective study for evaluating coronary microvascular dysfunction in patients with vasospastic angina

Prospective study for evaluating coronary microvascular dysfunction in patients with vasospastic angina - Prospective study for evaluating coronary microvascular dysfunction in patients with vasospastic angina

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019863

Enrollment

Registered

2015-11-24

Start date

2015-12-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vasospastic angina

Interventions

Evaluation for coronary microvascular dysfunction with Certus Pressure Wire during ACh provocation test

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients who planned to undergo ACh provocation test 2) Patients who discontinue coronary dilator >48 hours before ACh provocation test

Exclusion criteria

Exclusion criteria: 1) Patients with hemodialysis 2) Patients with severe hepatic disorder 3) Patients with severe heart failure (ejection fraction <30% or NYHA >class 3) 4) Patients with prior coronary intervention for left anterior descending artery

Design outcomes

Primary

Measure	Time frame
Comparison of the index of microcirculatory resistance (IMR) between patients with positive acetylcholine (ACh) provocation test and those with negative	—

Secondary

Measure	Time frame
1) Coronary flow reserve (CFR) in patients with positive or negative ACh provocation test 2) Relation between chest symptom and IMR or CFR 3) Relation between IMR or CFR and chest symptom in patients with negative ACh provocation test 4) IMR, CFR and mean transit time (MTT) which indicate coronary epicardial or microvascular spasm 5) Relation between reactive hyperemia index (RHI) and IMR, CFR, MTT, or positivity of ACh provocation test 6) Relation between RHI and chest symptom	—

Measure

Time frame

1) Coronary flow reserve (CFR) in patients with positive or negative ACh provocation test 2) Relation between chest symptom and IMR or CFR 3) Relation between IMR or CFR and chest symptom in patients with negative ACh provocation test 4) IMR, CFR and mean transit time (MTT) which indicate coronary epicardial or microvascular spasm 5) Relation between reactive hyperemia index (RHI) and IMR, CFR, MTT, or positivity of ACh provocation test 6) Relation between RHI and chest symptom

—

Countries

Japan

Contacts

Public ContactYuichi Saito

Chiba University Hospital Department of Cardiovascular Medicine

policemaccho@yahoo.co.jp043-222-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026