Efficacy of programmed intermittent bolus compared to continuous infusion in combination with patient-controlled epidural analgesia for postoperative pain management after pylorus-preserving pancreaticoduodenectomy

Efficacy of programmed intermittent bolus compared to continuous infusion in combination with patient-controlled epidural analgesia for postoperative pain management after pylorus-preserving pancreaticoduodenectomy - PIB in combination with PCEA

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019777

Enrollment

Registered

2015-11-16

Start date

2014-01-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic cancer

Interventions

Patients were assigned as a delivery method to 2 groups. Group P(programed intermittent bolus

4 or 6 ml every 60 min, PCA bolus

3 ml, lock out time

30 min) dose of intermittent bolus HT &lt

155 cm

4 ml HT &gt

6 ml HT: height Group C (continuous infusion

4 or 6 ml/h, PCA bolus

30 min) rate of continuous dose HT &lt

4 ml/h HT &gt

6 ml/h HT: height

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists physical status I or II Patients were scheduled for elective pylorus-preserving pancreaticoduodenectomy (PPPD) under epidural block and general anesthesia

Exclusion criteria

Exclusion criteria: Patients with respiratory disorder Patients with heart failure Patients with anticoagulant therapy Patients with obesity(BMI > 35)

Design outcomes

Primary

Measure	Time frame
1) Pain intensity at rest and during movement at 0, 2, 4, , 8, 12 postoperatively 2) Dose of PCA bolus for 12 hours 3) Dose of supplemental analgesic for 12 hours	—

Secondary

Measure	Time frame
1) Hemodynamic data (heart rate, blood pressure)at 0, 2, 4, , 8, 12 postoperatively 2) Adverse effects for 12 hours 3) Patient's satisfaction at 12 hr postoperatively	—

Countries

Japan

Contacts

Public ContactYukitoshi Niiyama

Sapporo Medical University School of Medicine Department of Anesthesiology

niiyama@sapmed.ac.jp011-611-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026