Dose-dependent effects of green tea catechin on pharmacokinetics of nadolol in healthy volunteers

Dose-dependent effects of green tea catechin on pharmacokinetics of nadolol in healthy volunteers - GT-nadolol interaction study 3

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019761

Enrollment

Registered

2015-12-01

Start date

2015-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

Subjects in this group receive 30 mg of nadolol orally with 300 mL of water after overnight fasting. In the second phase, subjects receive 30 mg of nadolol orally with 50 mg of green tea extract diss

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy volunteers

Exclusion criteria

Exclusion criteria: Smoker

Design outcomes

Primary

Measure	Time frame
Blood samples are collected before and at 0.5, 1, 2, 3, 4, 6, 8, 24,and 48 hours after nadolol administration. Urine samples are obtained over 48 hours after nadolol administration. Blood pressure and pulse rate are monitored before and at 0.5, 1, 2, 3, 4, 6, 8, 24, and 48 hours after nadolol adoministration.	—

Secondary

Measure	Time frame
Plasma concentrations of nadolol Urinary excretions of nadolol Blood pressure Pulse rate	—

Countries

Japan

Contacts

Public ContactOsamu Abe

Fukushima Medical University, School of Medicine Department of Phamacology

osamu-a@fmu.ac.jp024-547-1156

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026