A multicenter randomized controlled trial on early fluid resuscitation in extensively burned patients.

A multicenter randomized controlled trial on early fluid resuscitation in extensively burned patients. - Burn RCT on fluid resuscitation. (FORECAST Burn)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019740

Enrollment

100

Registered

2015-11-16

Start date

2016-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burn

Interventions

Dose of Ringer lactate solution (2mL*%TBSA*body weight divided by 2*8 hours is started/4mL*%TBSA*body weight divided by 2*8 hours is started) Initial resuscitation period (2 days/2 days)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with burn surface area of 20-80%TBSA and age >21 years old.

Exclusion criteria

Exclusion criteria: Cardiopulmonary arrest Chemical burn Electric burn Case with time interval beyond 4 hours after burn Case received fluid resuscitation before the arrival Comorbidity; heart disease, COPD, chronic renal failure, hepatic cirrhosis. Case combined trauma.

Design outcomes

Primary

Measure	Time frame
The respiratory dysfunction within 1 week after burn. (PaO2/FiO2 ratio)	—

Secondary

Measure	Time frame
1. Renal dysfunction within 1 week after burn. (serum creatinine and BUN) 2. Occurrence rate of abdominal compartment syndrome within 28 days after burn. 3. The 28-day and hospital mortality. 4. Fluid volume required within 48 hours after burn.	—

Countries

Japan

Contacts

Public ContactShuta Fukuda

Japanese Association for Acute Medicine Office

editorial-jaam@umin.net+81-3-5840-9870

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026