non-small cell lung cancer
Conditions
Interventions
A: Lung cancer surgery with hANP treatment [Patients in the hANP group receive human ANP (0.025 microgram/kg/min for 3 days), which is started more than two hours before surgery]
B: Surgery alone
Sponsors
National Cerebral and Cardiovascular Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Preoperative criteria 1. Non-small cell lung cancer is suspected. 2. Thin-section CT fulfills the proportion of maximum diameter of the tumor itself to consolidation is more than 0.25. 3. It's possible to perfom the complete resection including mediastinal lymph node dissection. 4. Patient without simultaneous or metachronous (within the past 5 years) double cancers. 5. Aged more than 20 years 6. Performance status of 0-2. 7. Sufficient organ functions. 8. All patients gave written informed consent
Exclusion criteria
Exclusion criteria: 1. Thin-section CT fulfills the proportion of maximum diameter of the tumor itself to consolidation is less than 0.25. 2. Patient with active the other concurrent malignant diseases. 3. Women during pregnancy or breast-feeding. 4. Psychosis. 5. Systemic steroids or immunosuppressive agents medication. 6. Uncontrollable infectious disease, autoimmune disease, or the other severe comorbidities. 7. History of right ventricular infarction. 8. Severe hypotension 9. Other conditions judged ineligible by physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinicopathological character, overall survival, disease-free survival and gene differentiation (including microRNA, cell free DNA, and MUC4 gene mutation) | — |
Countries
Japan
Contacts
Public ContactTakashi Nojiri
National Cerebral and Cardiovascular Center Research Institute/Osaka University Hospital Biochemistry/General Thoracic Surgery
Outcome results
None listed