Alzheimer'
Conditions
Interventions
11CPIB was injected intravenously as a bolus with a mean dose of 551.5 +- 39.7 MBq. Dynamic PET scanning in the three dimensional mode was performed for 60 min using a predetermined protocol of 31 fra
Sponsors
Shonan-Atsugi hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: AD subjects were older than 56 years, and met the core clinical criteria of the NIA Alzheimer's Association for probable AD. MCI subjects were older than 56 years, and met the Core Clinical Criteria for MCI proposed by the NIA Alzheimer's Association. The normal cognitive status of HC subjects was required to be a MMSE score of 28 or greater and a CDR score of 0. All subjects or their caregiver provided written informed consent for participation.
Exclusion criteria
Exclusion criteria: AD subjects were older than 56 years, and met the core clinical criteria of the NIA-Alzheimer's Association for probable AD. MCI subjects were older than 56 years, and met the Core Clinical Criteria for MCI proposed by the NIA-Alzheimer's Association. The normal cognitive status of HC subjects was required to be a MMSE score of 28 or greater and a CDR score of 0. All subjects or their caregiver provided written informed consent for participation. Participants were excluded if they had other systemic or brain diseases,including degenerative,vascular, depressive, traumatic, medical comorbidities, mixed disease, or traumatic brain injury.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cortical FMM SUVR in AD patients was significantly greater than in older HC subjects 1.76 +- 0.23 vs 1.30 +- 0.26, p<0.01. Six-eight MCI patients had a bimodal distribution of SUVR, and 29 of them 42.6% had positive scans. Cortical FMM SUVR values were strongly correlated with PIB DVR r=0.94, n=145, p<0.001. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cortical FMM SUVR was negatively correlated with MMSE scores r= -0.51, n=145, p<0.05 and positively with CDR SB scores r=0.49, n=145, p<0.05 when all groups were analyzed together. There was no significant difference in the mean cortical FMM SUVR between APOE 4 carriers and non-carriers in each group | — |
Countries
Japan
Contacts
Public ContactSizuo Hatashita
Shonan-Atsugi hospital Department of neurosurgery
Outcome results
None listed