Acute encephalitis and encephalopathy among pediatric patients
Conditions
Interventions
Therapeutic hypothermia (34 degree Celsius for 72 hours, followed by 48 hours of warming) using cooling pads.
Sponsors
Department of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Pediatric patients less than 18 years old, who are diagnosed as acute encephalitis / encephalopathy, with no improvement or progressive worsening. Acute encephalitis / encephalopathy would be diagnosed,when any findings as below are seen with no improvement within 3 hours: 1) acutely and moderately worsened consciousness level with JCS (Japan Coma Scale) more than 20, 2) mildly worsened consciousness level with JCS more than 10 lasting more than 24 hours, 3) accompanied with abnormal findings on head CT or head MRI, or 4) accompanied with abnormal EEG findings
Exclusion criteria
Exclusion criteria: Because coagulopathy are common during hypothermia, (1-1) Intracranial hemorrhage was seen on head CT or MRI, (1-2) Hemorrhagic diathesis, or (1-3) thrombocytopenia less than 50,000/mm3. Because immunosuppression are common during hypothermia, (2-1) Congenital immunologic disability (SCID, a-gamma-globurinemia, chronic granulomatous disease, et.al). Because circulation are easily suppressed during hypothermia, (3-1) Cardiac disease or arrhythmia, which need medication. (3-2) Decreased cardiac contractility (LVEF < 40% on echocardiogram) (3-3) Normal blood pressure is not maintainable even with catecholamines or vasopressors. Because this study needs informed consent from legal representatives, (4-1) When legal representatives denied to be participated, (4-2) When child abuse is strongly suspected, Or whenever the regarding physicians thought the patient is not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| If there occur any medical condition for which therapeutic hypothermia must be discontinued. | — |
Secondary
| Measure | Time frame |
|---|---|
| If there are seen more labo data, clinical signs, or monitored signs, that represent complications such as coagulopathy, infection, or worsened general conditions. | — |
Countries
Japan
Contacts
Public ContactAtsushi Numaguchi
Nagoya University Hospital Department of Emergency and Critical Care Medicine
Outcome results
None listed