Mood disorders (major depressive disorder and bipolar disorder) and healthy volunteers
Conditions
Interventions
For depressive patients, repetitive TMS will be applied with the following parameters below. Target location: left dorsolateral prefrontal cortex localized by a spatial navigation system Stimulation
s resting motor threshold Number of pulses: 2000-3000 pulses/day Number of total sessions: 20-30 sessions
For healthy-control individuals, causally examine regionally interconnected brain regions
Sponsors
Department of Psychiatry and Neurosciences, Graduate school of Biomedical and Health Sciences, Hiroshima University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: For patients/clients 1) Aged 20-80 years old 2) Being diagnosed as major depressive disorder or bipolar disorder (Type I, Type II) according to DSM-IV-TR or DSM-5 3) Current diagnosis of major depressive episode 4) Present treatment-resistance (scores with 14 points or above out of 17 items on the Hamilton Rating Scale for Depression even after >=4 weeks of treatment with sufficient amount of more than1 anti-depressant) or low treatment-tolerance (insufficient administration due to side-effects while taking more than 1 anti-depressant) 5) Satisfactory informed consent obtained from participant him/herself For healthy control 1) Aged 20-80 years old 2) No history of any psychiatric disorders 3) Not having current serious medical illness 4) Satisfactory informed consent obtained from the participant him/herself
Exclusion criteria
Exclusion criteria: Rejection criteria common to both patients and healthy controls 1) Decisionally impaired individuals who has diminished capacity to understand the aim of the research 2) Physically impaired individuals who are not able to complete the experiments 3) Subjects who are contraindicated for the use of TMS and MRI Having an implanted heart pace-maker Having implanted cerebral (arteries) clips Having implanted neural/nerve stimulators Having implanted pumps Having work experience in a metal industry or possibility of metal residues remaining in the body Having metal-tattoos (including tattooed eye-lining) Being pregnant, or having possibility of being pregnant 4) Subjects who are contraindicated for the use of TMS Personal history of seizure disorder such as epileptic disorder 5) Any individuals judged as inappropriate for the experiment by the principal investigator or a collaborating researcher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Using psychological assessments and neuroimaging techniques, we evaluate psychological and neural changes in depression-related symptoms, immediately after the intervention, one week later, one month later, and again six months later. | — |
Countries
Japan
Contacts
Public ContactGo Okada
IGraduate school of Biomedical and Health Sciences, Hiroshima University Department of Psychiatry and Neurosciences
Outcome results
None listed