Neuroimaging and neurophysiological analysis for electroconvulsive therapy (ECT)-related brain structure and function

Neuroimaging and neurophysiological analysis for electroconvulsive therapy (ECT)-related brain structure and function - Neuroimaging and neurophysiological analysis for electroconvulsive therapy (ECT)-related brain structure and function

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000019475

Enrollment

120

Registered

2015-10-23

Start date

2015-10-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression, bipolar disorder, schizophrenia, healthy control

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: <Major depressive disorder or bipolar disorder> 1. Inpatients in our hospital with diagnosis of bipolar I/II disorder, major depressive disorder 2. clinical indications for ECT (indication and informed consent for ECT treatment already obtained before recruitment independently of the study.) <Schizophrenia> 1. Inpatients in our hospital with a diagnosis of schizophrenia or schizoaffective disorder 2. clinical indications for ECT (indication and informed consent for ECT treatment already obtained before recruitment independently of the study.)

Exclusion criteria

Exclusion criteria: 1. Another major psychiatric illness 2. Current drug or alcohol dependence 3. Neurological or degenerative disorders (e.g. epilepsy, Alzheimer) 4. Unstable or severe medical illness (e.g. myocardial infarction within 1 month) 5. Pregnancy 6. ECT treatment within the last 3 months 7. Patients who cannot participate in the MRI scanning because of contraindications to MRI (e.g. pacemaker) 8. patients with mandatory admission by mayor of municipality

Design outcomes

Primary

Measure	Time frame
changes in brain structure (gray matter and white matter) and functional connectivity detected by MRI	—

Secondary

Measure	Time frame
Depressive symptom: Hamilton Depression Rating Scale (HAM-D), Montgomery-Asberg Depression Rating Scale (MADRS), Beck Depression Inventory (BDI) Manic symptom: Young Mania Rating Scale (YMRS) Psychomotor disturbance: The CORE Assessment Psychotic symptom: Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS) Psychotic Depression Assessment Scale (PDAS) Catatonic symptom: Bush-Francis Catatonia Rating Scale (BFCRS) Clinical Global Impression (CGI) Global Assessment of Functioning (GAF) Cognitive function: Mini-Mental State Examination (MMSE) QOL: EuroQOL EEG	—

Measure

Time frame

Depressive symptom: Hamilton Depression Rating Scale (HAM-D), Montgomery-Asberg Depression Rating Scale (MADRS), Beck Depression Inventory (BDI) Manic symptom: Young Mania Rating Scale (YMRS) Psychomotor disturbance: The CORE Assessment Psychotic symptom: Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS) Psychotic Depression Assessment Scale (PDAS) Catatonic symptom: Bush-Francis Catatonia Rating Scale (BFCRS) Clinical Global Impression (CGI) Global Assessment of Functioning (GAF) Cognitive function: Mini-Mental State Examination (MMSE) QOL: EuroQOL EEG

—

Countries

Japan

Contacts

Public ContactAkihiro Takamiya

Komagino Hospital Psychiatry

akihiro.takamiya@gmail.com042-663-2222

Outcome results