Healthy adults
Conditions
Interventions
Ingestion of 4 capsules containing powdered Saccharina sculpera 0.8g daily for 8 weeks.
Ingestion of 4 capsules containing dextrin daily for 8 weeks.
Sponsors
Hokkaido Information University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Subjects who have relatively low NK cell activity. 2.Subjects who agree to participate in the current clinical trial with a written informed consent.
Exclusion criteria
Exclusion criteria: 1.Subjects who are under treatment or medication for chronic inflammatory diseases, autoimmune diseases, allergies or thyroid disorders. 2.Subjects with serious cerebrovascular, cardiac, hepatic, renal, gastrointestinal, endocrine or metabolic disorders, or affected with infectious diseases which is required to report to the authorities. 3.Subjects who have a major surgical history such as gastrectomy, gastrorrhaphy, enterectomy or other serious gastrointestinal surgeries. 4.Pre- or post-menopausal women having complaints of obvious physical changes. 5.Subjects with unusually high and/or low blood pressure, and/or with abnormal hematological data. 6.Subjects with serious anemia. 7.Subjects with a history of allergy to medicine or food (especially seaweeds and gelatin). 8.Subjects who regularly take medicines, functional food or supplements (mushrooms, seaweed, nucleic acids, yeast, lactobacillus, etc.) which would affect the immune function, 9.Heavy smokers, alcohol addicts or subjects with irregular lifestyle 10.Subjects who donate either 400ml whole blood within 12 weeks or 200ml whole blood within 4 weeks or blood component(s) within 2 weeks prior to this study 11.Subjects who are pregnant or expected to be pregnant, or lactating during the study. 12.Subjects who participate in other clinical trials within the last one month prior to this study. 13.Any other medical reasons judged by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Natural Killer cell activity at 4 and 8 weeks after ingestion of test meals. | — |
Secondary
| Measure | Time frame |
|---|---|
| leukocyte differential count, IgM,IgA,IL-12,IL-2,IFN-gamma, flow cytometric lymphocyte subset analysis, VAS scores for fatigue, etc. and defecation frequency | — |
Countries
Japan
Contacts
Public ContactDir. Prof. Jun NISHIHIRA, M.D., Ph.D.
Hokkaido Information University Health Information Science Center
Outcome results
None listed