Efficacy of Autofluorescence imaging on flat adenoma detection; a randomized controlled trial

Conditions

Colonic neoplasm

Takeuchi Y, Mabe K, Shimodate Y, Yoshii S, Yamada S, Iwatate M, Kawamura T, Hotta K, Nagaike K, Ikezawa N, Yamasaki T, Komeda Y, Asai S, Abe Y, Akamatsu T, Sakakibara Y, Ikehara H, Kinjo Y, Ohta T, Kitamura Y, Shono T, Inoue T, Ohda Y, Kobayashi N, Tanuma T, Sato R, Sakamoto T, Harada N, Chino A, Ishikawa H, Nojima M, Uraoka T, Madowazu Study Group.

2019-07-1657 citations

10.7326/m19-0026

Efficacy of autofluorescence imaging for flat neoplasm detection: a multicenter randomized controlled trial (A-FLAT trial).

Takeuchi Y, Sawaya M, Oka S, Tamai N, Kawamura T, Uraoka T, Ikematsu H, Moriyama T, Arao M, Ishikawa H, Ito Y, Matsuda T.

2018-11-1621 citations

10.1016/j.gie.2018.11.012

Interventions

White light imaging Autofluorescence imaging (AFI)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients undergoing colonoscopy for investigation of FIT, surveillance after polypectomy, or investigation for minor symptoms. 2. Patients obtained written informed consent.

Exclusion criteria

Exclusion criteria: 1. Suspicious patient for advanced cancer. 2. Patient with IBD, polyposis, colon cancer, or colorectal polyps. 3. Patient with previous colorectomy or major abdominal surgery. 4. Patient with non-correctable coagulopathy. 5. Patient with severe organ failure.

Design outcomes

Primary

Measure	Time frame
detected number of flat colonic neoplasms per patient	—

Secondary

Measure	Time frame
detected number of colonic polyp per patient Adenoma detection rate Polyp detection rate Advanced neoplasia detection rate Detected number of advanced neoplasia per patient Detected number of sessile serrated adenoma/polyp (SSA/P) per patient Detected number of polyps according to morphology (flat/protruded) Detected number of adenomas according to the size. Procedure time (intubation and withdrawal time) Adverse events	—

Measure

Time frame

detected number of colonic polyp per patient Adenoma detection rate Polyp detection rate Advanced neoplasia detection rate Detected number of advanced neoplasia per patient Detected number of sessile serrated adenoma/polyp (SSA/P) per patient Detected number of polyps according to morphology (flat/protruded) Detected number of adenomas according to the size. Procedure time (intubation and withdrawal time) Adverse events

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Countries

Japan

Contacts

Public ContactYoji Takeuchi

Osaka International Cancer Institute Gastrointestinal Oncology

takeuti-yo@mc.pref.osaka.jp06-6945-1181

Outcome results

None listed