ischemic heart disease
Conditions
Interventions
Fractional flow reserve measurement with adenosine followed by nicorandil
Fractional flow reserve measurement with nicorandil followed by adenosine
Sponsors
Chiba University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with an angiographically intermediate lesion in a major epicardial coronary artery. Age between 20 and 89 years and signed informed consent.
Exclusion criteria
Exclusion criteria: Acute coronary syndrome within the previous 1 week,vessels with prior myocardial infarction, allergy to adenosine of nicorandil,asthma or chronic obstructive pulmonary disease on medical treatment, second or third degree atrioventricular block, severe valvular heart disease, acute decompensated heart failure, reduced left ventricular function (ejection fraction less than or equal to 30%), severe liver dysfunction, severe renal insufficiency, angle-closure glaucoma, patients who are taking phosphodiesterase type 5 (PDE5) Inhibitors, pregnancy, patients who were not suitable for enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FFR value | — |
Secondary
| Measure | Time frame |
|---|---|
| The time to hyperemia; the plateau time; fluctuation; the number of functionally significant stenoses (FFR<0.75, FFR less than or equal to 0.80); hemodynamic parameters, ECG change and symptoms during FFR measurement. | — |
Countries
Japan
Contacts
Public ContactTakeshi Nishi
Chiba University Graduate School of Medicine Department of Cardiovascular Medicine
Outcome results
None listed