The clinical research of the relationship between glycemic control evaluation and oxidative stress and vascular endothelial dysfunction in the diabetes patient, with Evaluation of a new measure of blood glucose variability ,"ADRR"

The clinical research of the relationship between glycemic control evaluation and oxidative stress and vascular endothelial dysfunction in the diabetes patient, with Evaluation of a new measure of blood glucose variability ,"ADRR" - ADRR (Average daily risk range) and oxidative stress/vascular endothelial dysfunction

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019292

Enrollment

Registered

2015-10-09

Start date

2015-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients on insulin therapy

Interventions

Johnson &amp

Johnson Blood glucose meter

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1)Patient who is doing a self monitoring of blood glucose and a self-insulin injection. (2) Patient who is doing the insulin injection from before more than 6 months at the registration. (3)Individual who has the ability of consent and can sign a written informed consent

Exclusion criteria

Exclusion criteria: (1)Individual who has a smoking habit. (2)Patient with depression, alcohol-dependent patient. (3)Cancer patient (4)Patient who has taken a medication which affects to blood glucose levels, such as steroid, anti-cancer agent and interferon. (5)Woman who is pregnant, or possibility of pregnant, or wishes to pregnant, or lactating (6)Individual who is considered unsuitable for inclusion by the attending physician.

Design outcomes

Primary

Measure	Time frame
ADRR(Average daily risk range) Oxidative stress marker (serum 3-nitro-tyrosine, urinary 8-OHdG / Cr, urinary 8-iso-PGF2 alpha / Cr) (After 4 months of start of the study)	—

Secondary

Measure	Time frame
Blood sugar-related inspection: HbA1c, glycated albumin, blood glucose level, 1.5-AG FMD:Flow Mediated Dilation High sensitivity CRP Urinary albumin / creatinine ratio	—

Countries

Japan

Contacts

Public ContactYuka Kuroshima

Kanazawa Medical University Daibetology & Endocrinology

naipicrc@kanazawa-med.ac.jp076-286-2211

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

The clinical research of the relationship between glycemic control evaluation and oxidative stress and vascular endothelial dysfunction in the diabetes patient, with Evaluation of a new measure of blood glucose variability ,&quot;ADRR&quot;