Normal glucose tolerance (NGT), Impaired glucose tolerance(IGT), Type 2 diabetes (T2DM)
Conditions
Interventions
None listed
Sponsors
Kobe university school of medicine, Diabetes and Endocrinoplogy
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Capable to be inserted cathter at three different site at both arm 2)The level of fasting plasma glucose less than 130 mg/dl
Exclusion criteria
Exclusion criteria: 1)Type 1 DM 2)Pancreatic diabetes 3)Medical history of gastrointestinal tract surgery 4)Having insulin antibody(>10%) 5)Treatment with any long-acting insulin 6)Treatment with steroid 7)Impaired liver function, defined as alanine aminotransferase >2 times upper limit of normal(HBC or HCV infection) 8) Impaired renal function defined as eGFR <60ml/min 9) Severe cardiac dysfunction (> NYHA 3) 10)Cancer and medical history of cancer 11)Pregnancy or breast feeding 12)Known or suspected abuse of alcohol, narcotics or illicit drugs 13)Mental retardation or dementia or other inappropriate persons judged by investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of the area under the glucagon curve during hyperglycemic clamp among three groups (NGT,IGT and T2DM) | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the area under the insulin curve during hyperglycemic clamp among three groups (NGT,IGT and T2DM) | — |
Countries
Japan
Contacts
Public ContactKazuhiko Sakaguchi
Kobe university school of medicine Diabetes and Endocrinoplogy
Outcome results
None listed