The effects of the combination of glucosyl-hesperidin and caffeine on serum triglyceride and visceral fat in human dose-finding study:Double-blind, placebo-controlled trial

The effects of the combination of glucosyl-hesperidin and caffeine on serum triglyceride and visceral fat in human dose-finding study:Double-blind, placebo-controlled trial - The effects of the combination of glucosyl-hesperidin and caffeine on serum triglyceride and visceral fat in human

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019241

Enrollment

Registered

2015-10-05

Start date

2013-04-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

moderately high body mass index (24-30 kg/m2) with 100-250 mg/dL serum triglycerid, healthy subjects

Interventions

Oral ingestion of the control food (placebo,1 g/day,tablets) for 12 weeks Oral ingestion of the test food 1 (containing 470 mg glucosyl hesperidin,1 g/day,tablets) for 12 weeks Oral ingestion of the t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: [1]20-65 years old male and female [2]serum triglyceride:100-250 mg/dL [3]body mass index(BMI):24-30 kg/m2

Exclusion criteria

Exclusion criteria: [1]Subjects with drug or food allergy [2]Subjects with a serious history in liver, kidney, heart, lung, or gastrointestinal (including gastric resection, except for the cecum resection) [3]Subjects who donated 400 mL blood within 12 weeks, 200 mL within 4 weeks, or plasmapheresis within 2 weeks before starting of ingestion [4]Subjects whose systolic blood pressure value are less than 90 mmHg [5]Heavy users of alcohol, heavy smokers [6]Subjects with extremely irregular eating habit, shifts workers, late-night workers [7]Subjects taking medication or functional foods, influencing the results of this study, such as medicine, foods for specified health use, health foods. [8]Subjects who drink a lot of drink containing caffeine (tea, coffee, Coke, etc) [9]Female subjects who wish to become pregnant during the study period, (including the case who is suspected of being pregnant), or are pregnant or in nursing. [10]Subjects participating in another study or finished prior study within 4 weeks [11]Subjects deemed unsuitable by the investigator

Design outcomes

Primary

Measure	Time frame
Abdominal fat area (subcutaneous fat area and visceral fat area) at 0 and 12-week ingestion period	—

Secondary

Measure	Time frame
At 0, 4, 8 and 12-week ingestion period [1]serum triglyceride [2]body weight [3]body mass index (BMI)	—

Countries

Japan

Contacts

Public ContactTatsuya Ohara

House Wellness Foods Corporation Research and Development Institute

Ohara_Tatsuya@house-wf.co.jp072-778-1127

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026