The comparison nasal high-flow oxygen therapy with large volume nebulization-based humidifier for patients after the extubation: randomized controlled study

The comparison nasal high-flow oxygen therapy with large volume nebulization-based humidifier for patients after the extubation: randomized controlled study - Prospective randomized controlled study of Nasal High-flow Oxygen Therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019238

Enrollment

180

Registered

2015-10-05

Start date

2015-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respitratory failure after extubation

Interventions

nasal high-flow oxygen therapy large volume nebulization-based humidifier

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Obtained a written informed consent 2. Patients received a mechanical ventilation for more than 24 hours 3. Patients who are admitted to the emergency department or ICU, and underwent a management of the mechanical ventilation and oxygen therapy by the stuff of the emergency department. 4. Patients who received extubation within 14 days after obtained the written informed consent 5. Patients with PaO2/FIO2 < 300 within 3 hours before extubation.

Exclusion criteria

Exclusion criteria: 1.Patients with severe facial injury 2.Pregnancy 3.Patients with tracheostomy 4.Patients who had pneumothorax without thoracic drainage 5.Patients advocate 'Do-not-intubate status' before included this study.

Design outcomes

Primary

Measure	Time frame
Re-intubation rate within a week	—

Countries

Japan

Contacts

Public ContactWataru Matsuda

National Center for Global Health and Medicine Emergency department

wmatsuda@hosp.ncgm.go.jp03-3202-7181

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026