Enhanced Detection of Underlying, Covert ATrial fibrillation using 7-day Holter Electrocardiogram in patients with Embolic Stroke of Undetermined Source

Enhanced Detection of Underlying, Covert ATrial fibrillation using 7-day Holter Electrocardiogram in patients with Embolic Stroke of Undetermined Source - EDUCATE-ESUS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000019170

Enrollment

200

Registered

2015-10-01

Start date

2014-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Embolic stroke of undetermined source

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Recent ESUS (within 3 months of onset) defined as: A. Recent ischemic stroke (including transient ischemic attack with positive neuroimaging) visualized by brain imaging that is not lacunar B. Absence of cervical carotid atherosclerotic stenosis > 50% or occlusion C. No atrial fibrillation after 24-hour cardiac rhythm monitoring D. No intra-cardiac thrombus on transthoracic echocardiography E. No other major cardioembolic sources F. No other specific cause of stroke (for example, arteritis, dissection, migraine/vasospasm, drug abuse) 2. 20 years of age or older 3. Signed written informed consent

Exclusion criteria

Exclusion criteria: 1. Any previously documented atrial fibrillation 2. Untreated hyperthyroidism 3. Pacemaker or ICD device implanted or planned to implant 4. Estimated life expectancy < 12 months 5. Examination of seven-day Holter ECG not applicable within 3 months after stroke onset. 6. Patients considered inappropriate to participate in the study

Design outcomes

Primary

Measure	Time frame
Detection of any atrial fibrillation by 7-day Holter ECG	—

Secondary

Measure	Time frame
1. Antithrombotic therapy before and after 7-day Holter ECG 2. Any ischemic or hemorrhagic event for 1 year after index stroke 3. Any adverse event related to 7-day Holter ECG	—

Countries

Japan

Contacts

Public ContactMiyazaki Yuichi

National Cerebral and Cardiovascular Center Department of Cerebrovascular Disease

ymiyazaki@ncvc.go.jp06-6833-5012

Outcome results