Survey on metformin-induced vitamin B12 deficiency in patients with type 2 diabetes

Survey on metformin-induced vitamin B12 deficiency in patients with type 2 diabetes - Survey on metformin-induced vitamin B12 deficiency in patients with type 2 diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000019126

Enrollment

300

Registered

2015-12-01

Start date

2016-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Type 2 diabetes 2)type 2 patients who taking metformin within the conditions specified in the product labeling

Exclusion criteria

Exclusion criteria: 1)Is receiving vitamin B12 preparation including vitamin B12 supplements 2)Is receiving steroids, and gastrectomy (include segmentectomy and total resection, but not endoscopic mucosal resection) 3)Is pregnant, nursing, or planned to become pregnant 4)With malabsorption(chronic pancreatitis,inflammatory bowel disease and malabsorption syndrome) 5)With severe infection, pre or post surgery, and serious trauma,malignancy 6)With renal dysfunction (Serum Creatinine male: >= 1.5 mg/dL, female: >= 1.3 mg/dL) 7)Considered as inadequate by the investigator

Design outcomes

Primary

Measure	Time frame
The corelation between the period of taking metformin and serum homocysteine or vitamin B12 level as the diagnostic index for vitamin B12 deficiency.	—

Secondary

Measure	Time frame
1)The corelation between the daily dose of metformin and serum homocysteine or vitamin B12 level as the diagnostic index for vitamin B12 deficiency. 2)The corelation between the cumulative dose of metformin and serum homocysteine or vitamin B12 level. 3)The relationship between macrocytic anemia and serum homocysteine or vitamin B12 level.	—

Countries

Japan

Contacts

Public ContactYuko Okada

Kobe University Graduate School of Medicine Division of Diabetes and Endocrinology

yokada@med.kobe-u.ac.jp078-382-5861

Outcome results