Pathophysiological roles of atherosclerotic carotid plaque phenotypes and bioactive substances in patients undergoing carotid endarterectomy

Pathophysiological roles of atherosclerotic carotid plaque phenotypes and bioactive substances in patients undergoing carotid endarterectomy - Pathophysiological characteristics of carotid plaque and circulating monocytes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000019115

Enrollment

Registered

2015-09-25

Start date

2011-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. Atherosclerosis 2. Stroke 3. Carotid stenosis 4. Diabetes

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Outpatients undergoing carotid endarterectomy in the Department of Neurosurgery of our hospital 2. Patients who are able to attend the hospital 3. Age: 20 years of age and older, and below 80 years old 4. Patients providing written informed consent

Exclusion criteria

Exclusion criteria: 1. Subjects who have been determined to be unsuitable for the attending physician

Design outcomes

Primary

Measure	Time frame
inflammatory mediators IL-6,IL-10,TNFalfa,MCP-1 activation/inflammatory markers in plaque and peripheral blood monocytes MHC-II, CD86, Dectin-1, CD206, CD16, CD68	—

Secondary

Measure	Time frame
body weight,BMI,waist circumference,blood pressure,HbA1c,FPG,TC,TG,LDL-C,HDL-C, UA,BUN,Cre	—

Countries

Japan

Contacts

Public ContactNoriko Satoh-Asahara

National Hospital Organization, Kyoto Medical Center Clinical Research Institute

nsato@kyotolan.hosp.go.jp075-641-9161

Outcome results