Hodgkin'
Conditions
Interventions
Omit radiation therapy for FDG-PET negative cases after 2 courses of multi-drug chemotherapy
Sponsors
Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) diagnosis of Hodgkin's lymphoma (2) age under 20 year old at diagnosis (3) registration at JPLSG CHM-14 study (4) written informed consent obtained from patient or guardians.
Exclusion criteria
Exclusion criteria: (1) Cases where impaired liver, kidney and cardiac functions compromise experimental treatment (2) Patients who have been treated with anticancer drugs or radiation therapy (3) Presence of CNS degenerative lesion (4) Associated intracranial hemorrhage which hinders execution of treatment process (5) Associated infection which is difficult to control (6) Pregnant or possibility of pregnancy (7) Women who are breastfeeding (8) Past history of malignant neoplasm or multiple primary neoplasms (9) History of congenital or acquired immune deficiency syndrome (10) Any other reasons that the attending physician has deemed unsuitable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5-year event-free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-year overall survival ratio of complete remission ratio of interim-PET negative ratio of acute and late side effect | — |
Countries
Japan
Contacts
Public ContactYuhki Koga
Graduate School of Medical Sciences Kyushu University Department of Pediatrics
Outcome results
None listed