The exploratory clinical study relates to the promoting effect and the safety of carbon dioxide transdermal absorption on the rehabilitation after total knee arthroplasty.

The exploratory clinical study relates to the promoting effect and the safety of carbon dioxide transdermal absorption on the rehabilitation after total knee arthroplasty. - The exploratory clinical study relates to the promoting effect and the safety of carbon dioxide transdermal absorption on the rehabilitation after total knee arthroplasty.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019069

Enrollment

Registered

2016-01-01

Start date

2016-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

Transcutaneous application of carbon dioxide 5 days between 7 and 14 days after surgery. Once a day for 20 minutes

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients received total knee arthroplasty in our hospital

Exclusion criteria

Exclusion criteria: active infection skin disease chronic obstructive pulmonary disease Deep vein thrombosis

Design outcomes

Primary

Measure	Time frame
Visual analog scale for pain 16 days after surgery	—

Secondary

Measure	Time frame
Knee range of motion 16 days after surgery	—

Countries

Japan

Contacts

Public ContactKoji Takayama

Kobe University Hospital Department of Orthopaedic Surgery

kojitakayama1978@gmail.com078-382-5985

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026