The accuracy of surgical pleth index (SPI) according to nicardipine or remifentanil intravenous infusion by comparing numerical changes of SPI value and end-tidal desflurane concentration during thyroid surgery: a prospective, single-centered, randomized , double-blind study.

The accuracy of surgical pleth index (SPI) according to nicardipine or remifentanil intravenous infusion by comparing numerical changes of SPI value and end-tidal desflurane concentration during thyroid surgery: a prospective, single-centered, randomized , double-blind study. - The accuracy of surgical pleth index (SPI) according to nicardipine or remifentanil intravenous infusion by comparing numerical changes of SPI value and end-tidal desflurane concentration

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019058

Enrollment

Registered

2016-02-01

Start date

2015-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who are undergoing elective thyroidectomy

Interventions

remifentanil 50ug bolus administration before skin incision, than administation remifentanil infusion 0.02ug/kg/min and titrate by 0.01ug/kg/min to maintaine mean arterial pressure between baseline M

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients aged 20-65 years with a physical status of 1 (the American Society of Anesthesiologists rating) who are scheduled to undergo elective thyroidectomy

Exclusion criteria

Exclusion criteria: Patients with a history of cardiovascular, respiratory (asthma), neurologic (seizure), kidney, liver disease, mood disorder, prematurity, or developmental delay, the presence of upper respiratory infection, hypersensitivity to drugs, and those receiving analgesics, sedatives or psychiatric medication will be excluded.

Design outcomes

Primary

Measure	Time frame
changes of SPI value during general anesthesia, change of desflurane concentration, hemodynamic change, recovery profiles and postoperative pain, analgesic requirement in adult whose age are from 20 to 65.	—

Countries

Asia(except Japan)

Contacts

Public ContactYoung ju Won

Guro Hospital, Korea University College of Medicine Department of Anesthesiology and Pain Medicine

moma2@naver.com82226261437

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026