Healthy adults
Conditions
Interventions
Apply the formulation including an active ingredient and placebo to both forearm skin respectively twice daily for 4 weeks
Sponsors
Kao Corporation
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Healthy male
Exclusion criteria
Exclusion criteria: -Subjects with cutaneous symptoms of atopic dermatitis -Subjects regularly going to hospital for sickness -Subjects undergoing hormone therapy - Subjects who are taking OCT or prescription medicine -Subjects with clinically-significant disorder (eczema, a scratch etc.) at the sites to be studied -Subjects participation in another clinical study accompanied by topical application of formulations and tape stripping or delipidation treatment to obtain experimental dry skin to the sites to be studied within the past 1 month. -Subjects take carbon dioxide bath or carbonated spring within the past 1 month. -Subjects deemed inappropriate to participate in this study by the principle investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Change of water content in stratum corneum after the topical application for 4 weeks -Change of NMF content in stratum corneum after the topical application for 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| -Change of epidermal thickness -Morphological change of epidermal cells -Change of the properties of fluorescence from epidermis -Change of the blood flow in skin -Change of the melanin content in epidermis | — |
Countries
Japan
Contacts
Public ContactKeiichi Sugata
Kao Corporation R&D -Core Technology- Biological Science Research
Outcome results
None listed