Hpercholesterolemic patients with type II diabetes
Conditions
Interventions
Pitavastatin 2mg, onece daily for 6 months
Sponsors
Fukui University School of Medical Science
Saiseikai Hospital Fukui Prefectural Hospital Yasukawa Hospital Fukui Chuo Clinic Tanaka Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who 1)are aged betwenn 20 and 80 years at time of consent and male or female 2)are mild diabetes mellitus by HbA1c < 8.4% (NGSP) 3)have Hypercholesterolemia with serum LDL-C levels of 120mg/dL or more or serum TC levels of 220mg/dl or more at baseline 4)provide written informed concent for participation in the study
Exclusion criteria
Exclusion criteria: 1) Patients with severe hepatic dysfunction 2) Patients with severe chronic renal dysfunction(serum Cr of 2.0 mg/dL or more) 3) Patients with severe cerebral vascular disease 4)Patients are judged as being inappropriate for this study by their own doctors 5) Patients are judged as being inappropriate for this study by investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amounts and percentages of canges in the following factors after 3-, 6-, and 12-month treatment 1) Changes in LDL and HDL suclasses and CETP 2) Changes in urinary LFABP 3) Changes in serum hs-CRP | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Amounts and pecentages of changes in following factors after 3-, 6-, and 12-month treatment 1)Serum lipid profile (TC,LDL-C, HDL-C, TG) 2) serum CETP 3) serum apolipoprotein A1, 4) serum adiponectin, 5) urinary albumin to creatinine ratio 6) urinary VEGF-(A, C) 2. Association analyses between percentage changes in subclasses of LDL or HDL and pretreatment levels of clinical factor 3. Association analyses between percentage changes in subclasses of LDL or HDL and | — |
Countries
Japan
Contacts
Public ContactHideki Kimura
University of Fukui Hospital Department of Clinical Laboratory
Outcome results
None listed