Efficacy of Rho-kinase inhibitor ophthalmic solution on bleb formation after trabeculectomy, a randomized parallel study

Efficacy of Rho-kinase inhibitor ophthalmic solution on bleb formation after trabeculectomy, a randomized parallel study - Efficacy of Rho-kinase inhibitor ophthalmic solution after trabeculectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000019017

Enrollment

Registered

2015-09-24

Start date

2015-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Open angle glaucoma

Interventions

0.4% ripasudil ophthalmic solution Twice daily For three months No use of 0.4% ripasudil ophthalmic solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have trabeculectomy as the therapy of open angle glaucoma which is not sufficiently controlled.

Exclusion criteria

Exclusion criteria: 1) Patients who had intraocular surgeries within six months. 2) Patients whose intraocular pressure are not able to be measured by Goldmann applanation tonometer. 3) Patients who had conjunctival surgeries (including glaucoma surgeries). 4) Patients who have an allergy to the ingredients of Rho-kinase inhibitor ophthalmic solution. 5) Patients who used Rho-kinase inhibitor ophthalmic solution before surgery. 6) Patients under the pregnancy or nursing. 7) Patients who are determined as an unsuitable person for this study by the doctor.

Design outcomes

Primary

Measure	Time frame
Transition of intraocular pressure for twelve months after surgery Bleb scoring at six months after surgery	—

Countries

Japan

Contacts

Public ContactHideaki Okumichi

Hiroshima University Hospital Department of Ophthalmology

okumic@hiroshima-u.ac.jp082-257-5247

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026