type2 diabetes mellitus
Conditions
Interventions
insulin treatment adding 5mg Dapagliflozin for 1 week.the attending physician dose of insuline adjusted according to the algorithm
insulin treatment not adding Dapagliflozin for 1 week. the
Sponsors
Toho University School of Medicine,Divsion of diabetes, metabolism and endocrinology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients with HbA1c over 10% (2) Patients who does not use human GLP-1 analog or insulin (3) Adalts who are 20 years or older (4) Patients who can understand consent brief and other explanation documents having the ability of the agreement about participation in this examination
Exclusion criteria
Exclusion criteria: (1) Type 1 diabetes mellitus patients or secondary diabetic mellitus (2) Patients who had myocardial infarction within 3 months, or obvious heart failure case (3) Patients who had the past of hypersensitivity for the used drug (4) Patients with diabetic ketoacidosis or diabetic coma or risk of diabetic coma (5) Patients with severe liver disease (6) Patients with severe renal disease (7) Patients with severe pancreas disease (8) Patients with hemoglobin (Hb) less than 11 g/dL (9) Patient during cancer treatment (10) Patients that the number of the platelets is less than 100,000 /mm3 (11) Patients with high diabetic neuropathy (12) Patients having a proliferative retinopathy (13) Patients with a serious infectious disease or a serious injury (14) Excessive common custom drinker (15) A pregnant woman or the woman who may be pregnant (16) In addition, the patient who judged inappropriate by an attendant physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.the dose of insulin and treatment period to manage hyperglycemia 2.measurement of energy expenditure and respiratory quotient by using the indirectcalorimetry | — |
Countries
Japan
Contacts
Public ContactUchino hiroshi
Toho University School of Medicine Divsion of diabetes, metabolism and endocrinology
Outcome results
None listed