LOw-Dose Tolvaptan in Decompensated Heart Failure Patients with Severe Aortic Stenosis - LOHAS registry -

LOw-Dose Tolvaptan in Decompensated Heart Failure Patients with Severe Aortic Stenosis - LOHAS registry - - LOHAS registry

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018966

Enrollment

Registered

2016-01-01

Start date

2016-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic stenosis

Interventions

(i) HF patients with severe AS who have already received standard therapy of HF. (ii) Registration is performed immediately after informed consent is obtained (within 24 hours after the admission)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Acutely decompensated HF patients (symptomatic) with severe AS (AVA<1.0 cm2) * Patients are diagnosed as CHF under Framingham heart failure diagnostic criteria.

Exclusion criteria

Exclusion criteria: 1. Patients presenting shock vital as <90 mmHg of systolic BP on admission 2. Patients suffering acute coronary syndrome within 30 days prior to admission 3. Patients with active systemic infection 4. Patients with hypernatremia

Design outcomes

Primary

Measure	Time frame
1. Change of body weight between admission and day 4 2. Daily and 4-days total of Urine volume and Fluid balance	—

Countries

Japan

Contacts

Public ContactYusuke Watanabe

Teikyo university school of medicine Cardiology

yusuke0831@gmail.com03-3964-1211

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026