beta-Thalassemia major
Conditions
Interventions
Our case control study included 80 children with BTM and 40 healthy children as controls. Assessment of unconventional T-lymphocyte populations was done by a sensitive three-color FACSCalibur flow cyt
Sponsors
Faculty of medicine, University of Assiut, Assiut 71516, Egypt.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The study included 3 groups; 40 BTM patients aged 3-8 years without splenectomy and 40 post-splenectomy BTM children aged 6-14 years. The two groups are on regular transfusion and chelation therapy, attending the Thalassemia Center, Pediatric Hematology Unit, Children Hospital Assiut University.
Exclusion criteria
Exclusion criteria: Patients with known diabetes, cardiac, renal, infectious, inflammatory or pulmonary diseases, newly diagnosed and non-transfusion dependent BTM cases were excluded from the study. Any patient had received any immunosuppressive medications e.g. steroids etc. during one month prior to enrollment were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The analysis of our data showed a significant high frequencies of CD4+CD8+ (double positive) T cells, CD4-CD8- (double negative) T cells and natural killer T cells in the peripheral blood of both BTM groups (splenectomized and non-splenectomized) as compared to healthy controls. | — |
Countries
Africa
Contacts
Public ContactAsmaa M. Zahran
Faculty of medicine, University of Assiut, Assiut 71516, Egypt. Clinical pathology department
Outcome results
None listed