Establish a new algorithm for antiviral therapies based on HCV NS5A mutation status in patients with chronic hepatitis C infection.

Establish a new algorithm for antiviral therapies based on HCV NS5A mutation status in patients with chronic hepatitis C infection. - New algorithm for antiviral therapies in patients with chronic hepatitis C.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018942

Enrollment

230

Registered

2016-01-01

Start date

2014-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with chronic hepatitis C infection

Interventions

asunaprevir, daclatasvir Simeprevir, peginterferon, ribavirin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) naive, null responder, patial responder 2) over 20 years old 3) HCV RNA level >100,000 IU/mL for naive patient 4) Dropout patients. 5) ban for pregancy 6) get informed concent

Exclusion criteria

Exclusion criteria: 1) liver failure 2) liver chrosis for SMV group 3) liver disease other than CHC 4) HCC 5) coinfection with HIV and/or HBV 6) other than genotype 1b 7) allegry for drugs i this study 8) contraindication for drugs in this study 9) pregnacy

Design outcomes

Primary

Measure	Time frame
SVR	—

Countries

Japan

Contacts

Public ContactKazuhiko Hayashi

Nagoya University Gastroenterology and hepatology

kazuh@med.nagoya-u.ac.jp052-741-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026