Impact of intravenous acetaminophen on multimodal pain management after total knee arthroplasty: a double-blinded randomized controlled trial

Impact of intravenous acetaminophen on multimodal pain management after total knee arthroplasty: a double-blinded randomized controlled trial - Impact of intravenous acetaminophen on multimodal pain management after total knee arthroplasty: a double-blinded randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018931

Enrollment

Registered

2015-09-07

Start date

2016-01-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis, Avascular necrosis of femoral condyle, Rheumatoid arthritis

Interventions

1000 mg of intravenous acetaminophen (100 ml) after total knee arthroplasty at 23:00 of day of surgery, 5:00, 11:00, 17:00, and 23:00 of one day after surgery, 5:00, 11:00, 17:00, and 23:00 of two day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients scheduled for unilateral total knee arthroplasty

Exclusion criteria

Exclusion criteria: Patients scheduled for simultaneous bilateral total knee arthroplasty. Patients scheduled for unilateral total knee arthroplasty combined with implant removal. Patients who had allergy or intolerance to one of the study drugs. Patients who received anticoagulant therapy. Patients who had poorly controlled diabetic mellitus, renal insufficiency, liver dysfunction and prolonged QT interval on ECG.

Design outcomes

Primary

Measure	Time frame
Visual Analogue Scale for postoperative pain at rest measured at 23:00 of day of surgery, 5:00, 11:00, 17:00, and 23:00 of one day after surgery, 5:00, 11:00, 17:00, and 23:00 of two days after surgery, and 5:00 of three days after surgery.	—

Secondary

Measure	Time frame
Complication Range of motion of the knee Consumption of rescue analgesia	—

Countries

Japan

Contacts

Public ContactOoiwa Minako

Nekoyama Miyao Hospital Department of Pharmacy

yakuzai@nekoyama.or.jp+81252822336

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026