NSAIDs-induced small-intestinal mucosal injuries
Conditions
Interventions
Regimens are as follows
Intervention A: indomethacin 25mg three times a day plus omeplazole 20mg once a day for seven days Intervention B:indomethacin 25mg three times a day plus omeplazole 20mg once a dayplus L-carnitine 1
Sponsors
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. healthy volunteers who have no comorbidities 2. all subjects are written informed consent
Exclusion criteria
Exclusion criteria: 1. subjects who are taking gastric acid-inhibitory drugs (H2-blocker or PPI) 2. subjects who have been already takeing NSAID 3. subjects who have contraindications for using NSAID (gastroduodenal ulcer, bronchial asthma including aspirin asthma, severe blood diseases/hapatic injuries/renal injuries/heart failure/hypertention/pancreatitis, pregnancy and lactation, triamterene users 4. past history of abdominal surgery or ileus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparing the severity of small-intestinal mucosal injuries in video-capsule endoscopy immediately after intervention between users of L-carnitine and non-users | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparing the levels of oxidative-stress marker and cytokines in the serum, and the composition of intestinal bacterial flora immediately after intervention between users of L-carnitine and non-users | — |
Countries
Japan
Contacts
Public ContactYoshiyasu Kono
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Gastroenterology and Hepatology
Outcome results
None listed