Effects of highly-bioavailable curcumin for periodontitis: a randomized, double-blind, placebo-controlled prospective study

Effects of highly-bioavailable curcumin for periodontitis: a randomized, double-blind, placebo-controlled prospective study - Effects of curcumin for periodontitis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018867

Enrollment

Registered

2015-08-31

Start date

2015-09-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis

Interventions

Inrervention-1: Theracurmin (contained 180mg of curcumin) Intervention-2: Placebo administration

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Individuals with chronic periodontitis patients with periodontal pocket from 5 to 7mm.

Exclusion criteria

Exclusion criteria: 1.Individuals with severe systemic deisease. 2. Individuals who are or suspected to be pregnant. 3. Individuals who take antiplatelet drug 4. Experience of taking any antibiotics within 6 months

Design outcomes

Primary

Measure	Time frame
Probing pocket depth Clinical attachment level Bleeding on probing Gingival index Plaque index Tooth mobility (Baseline, 1 and 2 month after baseline)	—

Secondary

Measure	Time frame
IL-1beta TNF-alpha IL-6 (Baseline, 2 month after baseline)	—

Countries

Japan

Contacts

Public Contactakizuki tatsuya

Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Department of Periodontology

akizuki.peri@tmd.ac.jp03-5803-5488

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026