Efficacy and safety of Antithrombin III administration for the patients with blood coagulation disorder after hepatectomy.

Efficacy and safety of Antithrombin III administration for the patients with blood coagulation disorder after hepatectomy. - Efficacy and safety of Antithrombin III administration for the patients with blood coagulation disorder after hepatectomy.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018852

Enrollment

140

Registered

2015-09-20

Start date

2015-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood coagulation disorder after hepatectomy

Interventions

A: Administration of gabexate mesilate 1,500mg per day for 4 days after surgery. B: Administration of gabexate mesilate 1,500mg per day for 4 days after surgery, and of antithrombin III 1,500mg for 2

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Hepatectomy for hepatic disease 2. Japanese Association for Acute Medicine-defined DIC criteria score > 4 on the day 1st after hepatectomy 3. Written informed consent 4. > = 20 years of age

Exclusion criteria

Exclusion criteria: 1. Clinically significant allergy 2. Clinically significant postoperative liver failure (T.Bil >=5.0mg/dL) 3. Clinically significant postoperative complication 4. Significant lack of antithrombin III (<30%) 5. Splenectomy 6. Presence of anastomosis of alimentary or biliary truct 7. Presence of biliary drainage 8. Clinically significant coagulopathy, renal disfunction or infection 9. Presence of psychological disorder

Design outcomes

Primary

Measure	Time frame
Efficacy (Posthepatectomy Liver Failure)	—

Secondary

Measure	Time frame
Safety, Morbidity rate, Mortality rate, Liver function test, Blood coagulation ability	—

Countries

Japan

Contacts

Public ContactKobayashi Tsuyoshi

Hiroshima University Hospital Gasroenterological Surgery

tsukoba@hiroshima-u.ac.jp082-257-5222

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026