A randomized control trial to prevent perioperative oxidative stress, inflammatory response and multiple organ injury after cardiovascular surgery by intravenous vitamin C: An electron spin resonance study

A randomized control trial to prevent perioperative oxidative stress, inflammatory response and multiple organ injury after cardiovascular surgery by intravenous vitamin C: An electron spin resonance study - A randomized control trial to prevent perioperative oxidative stress, inflammatory response and multiple organ injury after cardiovascular surgery by intravenous vitamin C: An electron spin resonance study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018805

Enrollment

100

Registered

2015-08-26

Start date

2015-08-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing cardiovascular surgery

Interventions

Intravenous vitamin C administration during perioperative period of cardiovascular surgery (intraopeative

1g X 2, postoperative

0.5g X 2 a day for 5days) Intravenous saline administration during perioperative period of cardiovascular surgery

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing cardiovascular surgery with American Society of Anesthesiologists (ASA) physical status class 1-3

Exclusion criteria

Exclusion criteria: Patients who have hypersensitivity to this agent or similar medicine. Pregnant patients or patients of child-bearing potential. Severe hepatopathic patients and severe kidney injury except dialysis patients. Patients whom the principal investigator judged to be inappropriate as a subject.

Design outcomes

Primary

Measure	Time frame
SOFA (sequential organ failure assessment) scores	—

Secondary

Measure	Time frame
Cardiac index Drainage in the First 24 Postoperative Hours Drainage in ICU Acute kidney injury RIFLE criteria ICU stay Hospital Stay Surgical new intervention reparation inflammatory markers oxidative stress markers stress hormones	—

Countries

Japan

Contacts

Public ContactShigekiyo Matsumoto

Oita University Anesthesiology

sigekiyo@oita-u.ac.jp097-586-5943

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026