Nagashima-type palmoplantar keratosis
Conditions
Interventions
The patients apply vaseline or 0.1% gentamicin topically to one of the hands with erythema and hyperkeratosis twice a day for 4 weeks.
The patients apply vaseline or 0.1% gentamicin topically to one o
Sponsors
Hokkaido University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: NPPK patients at the Hokkaido University hospital who fulfill the following criteria: 1.Patients aged 1 or older at the time of informed consent. 2.Patients who are homozygous or heterozygous for the mutation c.796C>T in SERPINB7. 3.Patients showing erythema and hyperkeratosis on both hands. 4.Patients giving written informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients who meet exclusion criteria of the drug. 2.Patients with severe complications who need hospitalization. 3.Patients who is considered to be inappropriate for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Improvement of skin symptoms such as erythema and hyperkeratosis. 2.Participants' self-assessment of improvement by VAS (Visual Analogue Scale). We evaluate skin symptoms 4 weeks after the treatment. | — |
Countries
Japan
Contacts
Public ContactYuka Ohguchi
Hokkaido University Graduate School of Medicine Department of Dermatology
Outcome results
None listed