Colon cancer
Conditions
Interventions
Enoxaparin group Subcutaneous injection of enoxaparin 2000U twice daily (postoperative day 2 to discharge) Intermittent pneumatic compression (IPC) prophylaxis (after surgery to postoperative day 1
Sponsors
Yokohama City University Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age of 20 years or older 2. Peformance status: 0 or 1 3. Elective laparoscopic colon cancer surgery 4. Tumor location: C, A, T, D, S, RS 5. No distant metastases by preoperative image findings within 28 days before registration 6. No deep venos thrombosis by preoperative ultrasonography within 28 days before registration 7. No preoperative treatment ( radiation, chemotherapy, etc) 8. Written informed consent after receiving explanation of the study
Exclusion criteria
Exclusion criteria: 1. Cotraindications of enoxaparin -Allergy for enoxaparin, heparin, and heparin derivatives -Bleeding or bleeding suspected -Acute bacterial endocarditis -Severe renal dysfunction -History of heparin-induced thrombocytopenia (HIT) 2. History of VTE 3. Receiving anticoagulants or antiplatelet drugs 4. Allergy for contrast media 5. Petients who are considered to be inappropriate for this trial by doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of venos thromboembolism until postoperative day 28 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Rate of bleeding events until discharge 2) Incidence of venos thromboembolism until discharge 3) Incidence of postoperative complications excluded venos thromboembolism | — |
Countries
Japan
Contacts
Public ContactMitsuyoshi Ota
Yokohama City University Medical Center Gastroenerological Center
Outcome results
None listed