Titration of heparin, measurement of heparin concentration in the blood, and determination of dose of protamine titrated with Hepcon in pediatric cardiac surgeries

Titration of heparin, measurement of heparin concentration in the blood, and determination of dose of protamine titrated with Hepcon in pediatric cardiac surgeries - Heparin concentration and protamine titration in pediatric cardiac surgeries

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018604

Enrollment

1000

Registered

2015-08-10

Start date

2015-08-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infants and children undergoing surgeries with cardiopulmonary bypass

Interventions

1) The larger dose of heparin of the dose indicated by Hepcon or the dose of 300 unit/kg is administered. 2) Additional heparin is administered during cardiopulmonary bypass. 3) The dose of protamin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Infants and children undergoing surgeries under cardiopulmonary bypass in Gifu Prefectural General Medical Center.

Exclusion criteria

Exclusion criteria: Patient without informed consent.

Design outcomes

Primary

Measure	Time frame
Activated coagulation time (ACT). Blood loss. The observation period is from the preoperative examination through the postoperative examination.	—

Secondary

Measure	Time frame
Value of fibrinogen in the blood. Platelet count in the blood. Heparin concentration in the blood.	—

Countries

Japan

Contacts

Public ContactTatsuhiko Masue

Gifu Prefectural General Medical Center Department of Anesthesiology

tatsuhikomasue@yahoo.co.jp058-246-1111ext.8088

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026