Healthy volunteer
Conditions
Interventions
Duration: 16 weeks Test material: test food 2 capsules per day (astaxanthin 12mg/day)
Duration: 16 weeks Test material: test food 2 capsules per day (astaxanthin 6mg/day)
Duration: 16 weeks
Sponsors
Nikoderm Research Inc.
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1)Japanese females aged 35-60 years old 2)Individuals who are healthy and do not treat any disease 3)Individuals who possesses wrinkles of the grade 3-5 (a Japanese perfumery academic meeting, guideline) degree in an outer corner of the eye 4)Individuals who worries about roughness 5)Individuals who sign the consent document after explanation of this study
Exclusion criteria
Exclusion criteria: 1)Individuals using medical products 2)Individuals with skin disease, such as atopic dermatitis 3)Individual who gets a tan excessively or Individuals who will get a tan excessively during the test period 4)Individual with fear who causes severe allergy in a food and medical supplies 5)Individual who is pregnant or lactate 6)Individual who have Severe hepatopathy, kidney or heart disease, lung disease, digestive organ disease(including stomach removal), organ obstacle disease, diabetes and thyroid disease, additionally, the individual with whom the past is infected in a severe disease 7)Individual who have a disease of hepatitis 8)Individual with high anemia 9)Individuals with possible changes of life style, such as working a night shift or conducting a long-term travel, during the test period 10)Individuals who are planning to take in the test duration again with the continual absorption custom of medical supplies, an unregulated drug, a preservation of health function food (specified health food), healthy food and supplement that we can think there is a possibility which influences a test result in present and within the for 3 months of past 11)Individuals who participated in other clinical studies in the past three months 12)Individuals who donated blood beyond 400ml in 200ml or within 3 months within the for 1 month of past 13)Individuals judged inappropriate for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The wrincle grade evaluated by a picture of eye area,The wrinkle depth evaluated by replica,The transepidermal water loss | — |
Secondary
| Measure | Time frame |
|---|---|
| The stratum corneum water content,The skin elasticity,The ratio of IL-1RA/IL-1alpha of skin corner layer | — |
Countries
Japan
Contacts
Public ContactYuki Yamashita
Nikoderm Research Inc. Department of evaluation
Outcome results
None listed