Japanese Longitudinal Biomarker Study in PSP and CBD

Japanese Longitudinal Biomarker Study in PSP and CBD - Japanese Longitudinal Biomarker Study in PSP and CBD (JALPAC)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000018468

Enrollment

150

Registered

2015-08-01

Start date

2014-11-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), corticobasal syndrome (CBS)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients 20 years of age or older who provide written informed consent 2) Healthy volunteers 20 years of age or older who provide written informed consent 3) Patients meeting the NINDS-SPSP diagnostic criteria (Litvan 1996) 4) Patients meeting the modified version of the Cambridge CBS diagnostic criteria (Mathew 2012) 5) Patients meeting the CBD diagnostic criteria (Armstrong 2013) 6) Patients who do not meet the diagnostic criteria of PSP/CBS, but clinically suspected as having these conditions

Exclusion criteria

Exclusion criteria: fulfill the diagnostic criteria of other neurodegenerative disorders

Design outcomes

Primary

Measure	Time frame
- Elucidation of the natural history - Development of new biomarker(s)	—

Secondary

Measure	Time frame
- Clinical evaluations including cognitive, language, oculomotor, and motor functions during the observation period. - Clinical severity - MRI (volumetric analysis) - Known CSF and blood biomarkers - Neuropathological examination	—

Countries

Japan

Contacts

Public ContactTakeshi Ikeuchi

Niigata University, Brain Research Institute Molecular Genetics

ikeuchi@bri.niigata-u.ac.jp025-227-2344

Outcome results